1．Academic Background
Research Scholar Associate (2008-2013) in Plant Molecular Biology in Crop & Soil Sciences in Washington State University
Ph.D. (2007-2012) in Genetics with the work on “Cultivation of Safe Wheat Variety for Celiac Patients” from NENU (China) and WSU (USA)
M.Sc. (2004-2007) in Botany from NENU
·B.Sc. (2000-2004) in School of Life Sciences from NENU
2．Fields
Molecular Biology, Genetics
Academic Contributions
It’s about a quarter of the world-wide annual protein consumption from plant are wheat proteins. Well celiac patients are intolerant to wheat low molecular weight (LMW) glutenins and gliadins, and they need to avoid the intake of wheat flour from diet. Ph.D Shanshan Wen tried to eliminate LMW glutenins and gliadins’ expressions by regulating the key factor of 5-methylcytosine DNA glycosylases in the endosperm. This led up to more than 75% decrease of the total protein contents of the two relevant protein families in some lines, which provide a new way for engineering safe wheat variety for celiac patients.
Honors
Reviewer for Nucleosides, Nucleotides and Nucleic Acids, Plant Journal
2015 Distinguished Doctoral Dissertation Award, Jilin Province
3．Teaching Experience
<Molecular Biology> English Course for Undergraduates
<Crop Stress Biology> for Graduate Students
4．Projects and Publications
Projects
1.Elite-Introducing Starting Fund “Screening Wheat New Lines by Regulating Wheat Drought-Tolerant-Relevant Genes’ Expression via CRISPR Technique”, 2014-2017
2.Tang Zhongying Breeding Institute “Establishment of Wheat Protoplast Transformation System”, 2014-2016
3.Tang Zhongying Breeding Institute “Wheat Genetic Transformation Platform Program”, 2015-2019
4.Wheat Biology Basic Research Program from State Key Laboratory of Crop Stress Biology for Arid Areas “Wheat Microspore Tissue Culture for Callus Regeneration and Chromosome Doubling”, 2014-2016
5.Fundamental Research Funds for the Central Universities “ Preliminary Study on Wheat Drought-Tolerance Mechanism by Upregulating Wheat Aquaporin Expression via CRISPR Technique”, 2015-2018
6.Tang Zhongying Breeding Institute “Identification of Wheat Aquaporin Genes”, 2016-2018
7.The National Key Research and Development Program of China “High Efficiency Water-Saving Irrigation Technology and Integrated Application in Northwest Typical Farm Areas” sub project “Crop High Efficiency Water Use Mechanism and Regulation Research”, 2016-2020
Publications
1.Yang C, Zhao L, Zhang H, Yang Z, Wang H, Wen S, Zhang C, Rustgi S, von Wettstein D, Liu B. Evolution of physiological responses to salt stress in hexaploid wheat. Proc Natl Acad Sci USA. 2014, 111(32):11882-7.
2.Yang MM, Wen SS, Mavrodi DV, Mavrodi OV, von Wettstein D, Thomashow LS, Guo JH, Weller DM. Biological control of wheat root diseases by the CLP-producing strain Pseudomonas fluorescens HC1-07. Phytopathology, 2014, 104(3):248-56.
3.Rustgi S, von Wettstein D, Ankrah N, Mejias JH, Brew-Appiah R.A.T, Wen S, Wen N, Osorio C, Gemini R, Reisenauer P. Mohan J, Brabb I. A natural dietary-therapy for gluten intolerance, sensitivity, and allergenicity. Annual Wheat Newsletter, 59, 2013, 151-5.
4.Wen S, Wen N, Pang J, Langen G, Brew-Appiah RA, Mejias JH, Osorio C, Yang M, Gemini R, Moehs CP, Zemetra RS, Kogel KH, Liu B, Wang X, von Wettstein D, Rustgi S. Structural genes of wheat and barley 5-methylcytosine DNA glycosylases and their potential applications for human health. Proc Natl Acad Sci USA, 2012, 109(50):20543-8.
5.Rustgi S, von Wettstein D, Ankarah N. Brea-Appiah RAT, Wen S, Wen N, Osorio, C. Gemini R, Reisenauer P, Lu X, Mejias JH, Engineering wheat for celiac patients. Annual Wheat Newsletter, 57, 2011, 248-253.
6.Wen S, Kannangara G, Rustgi S, Claar, M, Langen, G, Pang, J, von Wettstein, D, Epigenetic Regulation of Wheat Gliadin and Low Molecular Weight Glutenins. Joint annual meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists, Montreal, Canada, July 31-August 4, 2010
7.von Wettstein D, Rustgi S, Kannangara CG, Ankrah N, Wen S, Brew-Appiah RAT, Wen N, Gemini R, Brueggeman R, Reisenauer P, Gill KS, Liu B, Pang J, Wang X, Claar M. Langen G, Kogel KH, A multipronged approach to develop nutritionally improved celiac safe wheat varieties. Annual Wheat Newsletter, 56, 2010, 261-264.
8.Li G, Song K, Feng K, Wen S, Liu L, Xu S, A construction of high efficient vector for high oleic and selectable marker free peanut, Arachis hypogaea. Journal of Northeast Normal University (Natural Science Edition), 2007, 39(2): 97-102.
9.Feng K, Wen S, Liu L, Xu S, A study on agrobacterium-mediated genetic transformation of peanut. Journal of Northeast Normal University (Natural Science Edition), 2006, 38(2): 37-40.
10.Wen S, Yang X, Feng K, Wang D, Liu L, Peanut transformation of sucrose synthase gene mediated by Agrobacterium tumefaciens, Memoir of Plant Genomics in China IIX, Harbin, Aug 8-10, 2006, 7: 202.
11.Rustgi S,Wen N,Osorio C,Brew-Appiah R.A.T,Wen S,Gemini R,Mejias JH,Ankrah N,Moehs CP,vonWettstein D,Natural dietary therapies for the gluten syndrome <http://scm.nsfc.gov.cn/scmwebsns/publication/viewSimple?des3Id=rALagw5ENK3l3AHaAVYNvA==,1>, Det kongelige danske videnskabernes selskab, Danmark, 2014
5．Contact
Address: No.3 Taicheng Road, Yangling, Shaanxi, China, 712100
Email: sswen@nwsuaf.edu.cn
